Harald Kolmar
Professor Technical University of Darmstadt
Harald Kolmar is full professor at the Technical University of Darmstadt, Germany where he heads the Department of Applied Biochemistry. His current scientific interests mainly focus on protein engineering and design, nanobiotechnology, antibody engineering, ADC generation and and development of tailor-made proteins for applications in diagnostics and therapy.
Seminars
Thursday 9th July 2026
Engineering Functional Bispecific Cytokine Agonists: Comparing Antibody–Cytokine Fusions & VHH-Derived Agonist Bispecifics
12:10 pm
- Reframing cytokines by attenuation of potency and cis activation
- Contrasting antibody cytokine fusions versus VHH-based strategies to highlight key trade-offs in potency, receptor geometry, selectivity, and safety
- Optimising on-target immune agonism through rational format and engineering choices to maximise efficacy while minimising systemic toxicity
