Harald Kolmar
Department Head Technical University of Darmstadt
Seminars
Thursday 9th July 2026
Engineering Functional Bispecific Cytokine Agonists: Comparing Antibody–Cytokine Fusions & VHH-Derived Agonist Bispecifics
2:00 pm
- Reframing cytokines by attenuation of potency and cis activation
- Contrasting antibody cytokine fusions versus VHH-based strategies to highlight key trade-offs in potency, receptor geometry, selectivity, and safety
- Optimising on-target immune agonism through rational format and engineering choices to maximise efficacy while minimising systemic toxicity
