Preclinical Safety Assessment of Dual ‘AND’ TCEs: Challenges in Selecting Good Target Pairs

• Preclinical development of a dual-targeting T-cell Engager (TCE) – AMG 305
• Leveraging different techniques in a weight of evidence (WoE) approach to uncover target co-localisation in normal human tissues
• Challenges with relevant species determination for AND-gated targets

Speakers:

Petra Lutterbuese

Senior Principal Scientist

Amgen