Fireside Chat: How Can We Predict Clinical Reality Through Preclinical Models & Translational Strategies?
- Which preclinical models have proven most predictive for bispecifics, TCEs, and ADCs- including safety and immunogenicity risk, and which consistently fail to translate?
- How do teams combine in vitro, in vivo, and computational approaches to reduce uncertainty before first-in-human studies?
- What translational signals provide sufficient confidence to advance a program, and how do teams actively manage remaining risk?